Rebbi said that in the future Rome will fall at the hands of Persia…. Rav said that Persia will fall at the hands of Rome. Rav Kahana and Rav Asi said to Rav: Can the builders [Persia, who permitted the rebuilding of the Holy Temple] fall before the destroyers [Rome, who destroyed the Temple]?![4] He said to them: Yes, it’s a decree of the King.[5]
Tosefos[6] reiterates that Persia is the nation destined to fall and adds a critical element: “We were told that in the future Persia will fall at the hands of Rome, that is, at the time of the coming of Moshiach.” Meaning, it’s not just one of many future events, but an event immediately preceding (-סמוך ל) the coming of Moshiach!